Find the DigitalProductID by this way: HKEY_LOCAL_ MACHINE SOFTWARE Microsoft windows NT Currentversion. Sent with Email: If you purchased Windows 10 online, you may find the license key is included in an email that Microsoft sent you at the time of purchase. Stored on Windows Registry: To view your Windows 10 product key in the Windows Registry: Press 'Windows + R' to open Run, enter 'regedit' to open Registry Editor. You will find the DigitalProductID in registry, but you can't read it normally without a third party help. If you bought a computer installed with Windows 10, you may find the serial key on the Microsoft-branded sticker on your PC case. Bcs classification system • 1. BIOPHARMACEUTICS CLASSIFICATION SYSTEM • Contents• Introduction• Overview of the Classification system• Applications• Conclusion• References • Introduction ۞Biopharmaceutics Classification System (BCS)♥ Scientific framework for classifying drug substances based on their aqueous solubility and intestinal permeability What is the need for a classification based on biopharmaceutics of the drug? Its importance in determining bioavailability • ORAL ROUTE♠ Route of choice for the formulators Continues to dominate the area of drug delivery technologies. LIMITATIONS Absorption and Bioavailability in the milieu of gastrointestinal tract. Limitations more prominent with the advent of protein and peptide drugs compounds emerging as a result of combinatorial chemistry and the technique of high throughput screening • API structure salt form and excipients Bioavailability of drug is determined byextent of drug solubility and permeability drug solubility drug product quality attributes • Biopharmaceutics Classification System Guidance provided by the U.S. Youtube tamil serials list. Food and Drug Administration for predicting the intestinal drug absorption The fundamental basis established by Dr. Gordon Amidon Distinguished Science Award (Aug ’06,FIP) First introduced into regulatory decision-making process in the guidance document on Immediate Release Solid Oral Dosage Forms: Scale Up And Post Approval Changes • Drug development tool that allows estimation of the contributions of 3 major factors, that affect oral drug absorption from immediate release solid oral dosage forms Dissolution Solubility Intestinal permeability. • Leaving or taking a message (When the person you’re calling isn’t available, be prepared to leave a message) • Can I leave a message?/ can I take a message? Biopharmaceutical Classification Of DrugsThe Biopharmaceutical Classification System (BCS) has been a prognostic tool for assessing the potential effects of formulation on the human drug oral bioavailability. When used in conjunction with in vitro dissolution tests, the BCS can support the prediction of in vivo product performance and the development of mechanistic models that support formulation assessments through the generation of “what if” scenarios. To date, the applicability of existing human BCS criteria has not been evaluated in dogs, thereby limiting its use in canine drug development. Therefore, we examined 50 drugs for which absolute bioavailability ( F) was available both in dogs and humans. The drugs were also evaluated for any potential association between solubility (calculated from the dose number, Do) or lipophilicity (LogP) and F in dogs. In humans, solubility is determined in 250 mL of fluid.
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